毛细支气管炎患儿外周血白细胞介素-12的意义

目的探讨白细胞介素（interleukin，IL）-12在毛细支气管炎发病过程中的意义。方法选取59例2岁以下毛细支气管炎患儿，分为毛支Ⅰ组（n=28）和毛支Ⅱ组（n=31），其中毛支Ⅰ组为具有特应质高危因素的患儿，毛支Ⅱ组为无特应质高危因素的患儿。同期住院的同年龄段支气管肺炎患儿36例和患有疝气、肾结石等非感染性疾病术前患儿31例分别作为肺炎对照组和正常对照组，分别检测4组患儿外周血IL－12的水平。结果毛支Ⅰ组患儿外周血IL-12为（34．72±7．96）pg／ml；毛支Ⅱ组患儿外周血IL-12为（55．30±6．72）pg／ml；肺炎对照组患儿及正常对照组患儿外周血IL-12分别为（56．79±10．36）pg／ml、（61．23±11．51）pg／ml，其中毛支Ⅰ组与毛支Ⅱ组相比，外周血IL-12水平降低，差异有统计学意义（P〈0．05）；毛支Ⅰ组与肺炎对照组、正常对照组相比，外周血IL-12水平显著降低，差异有统计学意义（P〈0．05）；毛支Ⅱ组与肺炎对照组、正常对照组相比，外周血IL-12水平降低，差异有统计学意义（P〈0．05）；肺炎对照组与正常对照组相比，外周血IL-12水平差异无统计学意义（P〉0．05）。结论血清IL-12降低是毛细支气管炎发病的重要因素，具有特应质高危因素的毛细支气管炎患儿IL-12降低更为明显。

Significance of peripheral blood interleukin-12 in capillary bronchiofitis patients

Objective To discuss the role of interleuldn（IL）-12 in capillary bronchiolitis disease. Methods Fifty-nine cases of capillary bronchiolitis children under 2 years old were enrolled as the bronchiolitis group Ⅰ（n = 28）and bronchiolitis group Ⅱ（n = 31 ） ,36 cases of children with bronchopneumonia of the same age and 31 cases of children suffered from non-infectious diseases such as hernia and renal calculus of the same age were enrolled as bronchopneumonia control group and normal control group respectively. The peripheral blood IL-12 levels of four groups were detected by enzyme-linked immunosorbent assay. Results The levels of the peripheral blood IL-12 in bronchiolitis group I,bronchiolitis group Ⅱ, bronchopneumonia control group and normal control group were （34. 72 ±7. 96） pg/ml, （55. 30 ±6. 72） pg/ml, （56. 79 ±10. 36） pg/ml and （61.23 ±11.51 ） pg/ml respectively. The level of the peripheral blood IL-12 in bronchiolitis group Ⅰ was significantly lower than that in bronchiolitis group Ⅱ, bronchopneumonia control group and normal control group respectively （P 〈 0. 05）, and the level of the peripheral blood IL-12 in bronchiolitis group Ⅱ was significantly lower than that in bronchopneumonia control group and normal control group respectively （ P 〈 0.05 ）, but there was no significant difference between bronchopneumonia control group and normal control group （ P 〉 0. 05 ）. Conclusion The level of IL-12 is one of the important factors for bronchiolitis disease,the reducing of serum level of IL-12 in children who have a high risk factor of capillary bronchiolitis is more obvious.