早产儿胃肠外营养相关性胆汁淤积的治疗现状

胃肠外营养是救治早产儿及危重新生儿的重要措施.近年来,随着围生期抢救技术的提高,越来越多的早产儿得以存活,极低出生体重儿、超低出生体重儿逐渐成为新生儿疾病谱的重要组成部分。这些早产儿常有胃肠道发育不成熟或合并其他疾病,在出生后的相当长一段时间内需要部分或完全的胃肠外营养支持。由于胃肠外营养的使用,为此类患儿提供了生存机会,大大降低了病死率,但其引起的胃肠外营养相关性胆汁淤积,则成为早产儿的主要并发症之一,严重影响患儿的生存质量。该文就早产儿胃肠外营养相关性胆汁淤积的治疗现状作一综述。

Treatment status of parenteral nutrition-associated cholestasis in preterm infants

Parenteral nutrition （PN） is one of the important measures to cure premature babies and critically ill infants.In recent years,with the improvement of rescue techniques in the perinatal period,a growing number of preterm infants alive,very low birth weight and low birth weight infants gradually become an important part of the neonatal disease.The gastrointestinal development of these premature babies are not mature or combined with other diseases,in a long period of time after birth need partial or complete PN support.Due to the use of PN,provides the children with survival and greatly reduce the case fatality rate,but the cause of parenteral nutrition associated cholestasis would become one of the main complications of premature infants,seriously affect the patient＇s quality of life.In this paper,the treatment of premature parenteral nutrition associated cholestasis status is summarized.