RESPIRATORY AND HYPNOTIC EFFECTS OF NITRAZEPAM, DIAZEPAM AND PENTOBARBITONE AND THEIR SOLVENTS IN THE RABBIT AND THE MOUSE |
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| Authors: | BRADSHAW, ELIZABETH G. PLEUVRY, BARBARA J. |
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| Affiliation: | Research Department of Anaesthesia and Pharmacology, University of Manchester
*Present address: Department of Anaesthetics, Royal Infirmary, Glasgow, Q4 |
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| Abstract: | Nitrazepam and diazepam only cause significant depression ofrespiratory rate and loss or righting reflex, in mice, at lethaldoses. In sub-lethal doses they induce a stage of deep but rousablesleep which is quite distinct from the intermittent dozing ofcontrol mice and the comatose state of mice injected with pentobarbitone.However, the respiratory effects of nitrazepam and diazepamin high doses in mice and low doses in rabbits are modifiedby the presence of solvent. Furthermore the solvent itself causesa loss of righting reflex in mice and the lethal dose of nitrazepamand diazepam is greatly reduced when the drugs are administeredin solvent |
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