HLA and Kaposi''s sarcoma in Sardinia |
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| Authors: | L. CONTU D. CERIMELE A. PINTUS F. COTTONI G. LA NASA |
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| Affiliation: | Department of Internal Medicine and Tissue Typing Laboratory, University of Cagliari, Cagliari.;Department of Dermatology, University of Sassari, Sassari, Italy. |
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| Abstract: | Twelve Sardinian patients affected by histologically defined classic Kaposi's sarcoma (KS) were HLA-A, B, C and DR typed. Compared to 220 age and ethnically matched healthy controls, KS patients showed a significant increase in HLA-DR5 (66.6 vs 23.1%, P less than 0.001) and a considerable decrease in HLA-DR3 (8.3 vs 53.6%, P = 0.0055). No definite association was observed for other HLA antigens. These results confirm the existence of an HLA associated genetic control of KS susceptibility and support the hypothesis that HLA-DR5 plays the role of a predisposition marker while HLA-DR3 bears a genetic resistance to the disease. |
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