CD44在肝细胞癌及癌周组织中的表达及其意义

 目的 研究CD44s及CD44v6蛋白在人肝细胞癌组织中表达及其意义。方法 应用免疫组化方法检测42例人肝细胞癌及其癌周组织与10例正常肝组织标本的CD44s及CD44v6表达情况。结果 CD44s及CD44v6在肝癌组织中表达明显高于癌周及正常肝组织，与门静脉内癌栓、包膜浸润及分化程度密切相关（分别为P＜0.01，P＜0.05，P＜0.05）。生存时间2年及2年以上组CD44s及CD44v6阳性表达分别为17.6 %（3／17），5.8 %（1／17），生存时间短于2年分别为52.6 %（10／19），42.2 %（8／19）（P＜0.05）。结论 肝细胞癌组织中CD44的表达与细胞分化、浸润转移密切相关，其阳性表达有助于判断预后。

Expression of CD44 in hepatocellular carcinoma and adjacent tissues and Its significances

Objective To investigate the expression of CD44 protein in hepatocellular carcinoma and clinical significances. Methods Immunohistochemistry was performed to examined 42 cases with hepatocellular carcinoma (HCC) and adjacent tissues and 10 cases of normal liver tissues for expression of CD44s and its isoforms CD44v6 proteins. Results Expression of CD44s and CD44v6 were all significantly higher in HCC tissues than it's surrounding liver and normal control, furthermore, be significantly correlated with the portal vein tumorous emboli, histological capsular infiltration and differentiation degree(P < 0.01, P < 0.05, P < 0.05, respectively). The positive expression of CD44s and CD44v6 were 17.6 %, 5.8 % respectively in groups that survival time was longer than or equal to two years, while 52.6 %, 42.2 % respectively less than two years(P < 0.05). Conclusion Expression of CD44s and CD44v6 is significantly correlated with differentiation, invasion and metastasis of HCC, and it is helpful to judge prognosis.