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Autoimmunity in ocular and generalised myasthenia gravis |
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| Authors: | M. J. Garlepp R. L. Dawkins F. T. Christiansen J. Lawton G. Luciani J. McLeod J. Bradley G. Genkins C. S. Teng |
| Affiliation: | 1. Department of Clinical Immunology, Royal Perth and Sir Charles Gaindner Hospitals and The University of Western Australia, Perth, W.A. Australia;2. Department of Pathology, Queen Mary Hospital Compound, Hong Kong;3. Istituto di Clinica Chirurgia, Università Cattolica del Sacro Cuore, Via Pineta Sacchetti 526, I-00168 Rome Italy;4. Department of Medicine, University of Sydney, Sydney, N.S.W. 2000 Australia;5. Department of Clinical Immunology, Flinders University, Bedford Park, S.A. 5042 Australia;6. Mount Sinai School of Medicine, City University of New York, New York, NY U.S.A. |
| Abstract: | Restricted ocular myasthenia gravis (OMG) and generalised myasthenia gravis (GMG) have been shown to differ in a number of respects. In OMG, anti-acetylcholine receptor, antistriational and antinuclear antibodies were rare relative to their frequency in GMG. In contrast, antithyroid antibodies and a history of thyroid disease were much more prevalent in OMG than in GMG. OMG was not associated with the female predominance seen in GMG and appeared to be relatively common in some races rather than others. It is suggested that different pathogenetic mechnisms are responsible for these two forms of MG. |
| Keywords: | Correspondence to: Associate Professor R.L. Dawkins Department of Clinical Immunology Royal Perth Hospital Wellington Street Perth Western Australia 6009 Australia. |
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