Role of various types of serotonin receptors in regulation of drinking behavior and salt appetite in vasopressin-deficient brattleboro rats |
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| Authors: | Naumenko K S Popova N K Ivanova L N |
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| Institution: | (1) Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk |
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| Abstract: | Serotonin 5-HT1A receptor agonist 8-OH DPAT suppressed drinking behavior in Brattleboro and Wistar rats. 5-HT1B agonist CGS-12066A and 5-HT2A antagonist ketanserin did not affect drinking behavior in Brattleboro rats; 5-HT3 antagonist ondansetron suppressed water consumption and 5-HT1A agonist stimulated salt appetite in Brattleboro, but not in Wistar rats. Presumably, vasopressin regulates thirst and salt appetite by modulating sensitivity/density of various types of 5-HT receptors. |
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| Keywords: | 5-HT1A 5-HT1B 5-HT2A 5-HT3 receptors drinking behavior salt appetite Brattleboro rats |
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