| 姬松茸多糖对2型糖尿病大鼠脂滴包被蛋白表达的影响 |
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| 引用本文： | 杨旭东,张杰,崔荣军. 姬松茸多糖对2型糖尿病大鼠脂滴包被蛋白表达的影响[J]. 内科急危重症杂志, 2011, 17(1): 21-23 |
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| 作者姓名： | 杨旭东 张杰 崔荣军 |
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| 作者单位： | 牡丹江医学院,牡丹江,157011 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 目的：探讨姬松茸多糖（ABPS）对2型糖尿病（2-DM）大鼠胰岛素抵抗和脂滴包被蛋白（Perilipin）基因表达的影响。方法：将Wistar大鼠随机分为5组,正常对照组（A组）、模型组（B组）、ABPS高剂量组（C组）、ABPS中剂量组（D组）、ABPS低剂量组（E组）。8周后,测定FBG、FINS和血脂水平;RT-PCR检测Perilipin基因的表达水平。结果：与模型组比较,ABPS组FBG、FINS、TC、TG、LDL-C、FFA降低,Perilipin基因的表达增加（P〈0.05）。结论：ABPS可改善糖脂代谢紊乱,降低胰岛素抵抗,其作用可能是通过提高Perilipin基因表达实现。
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| 关 键 词： | 姬松茸多糖 2型糖尿病 胰岛素抵抗 血脂 脂滴包被蛋白 |
Effect of Agaricus blazeiMurill Polysaccharides on Expression of Perilipin in Rats With Type 2 Diabetes Mellitus |
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| YANG Xudong,ZHANG Jie,CUI Rongjun. Effect of Agaricus blazeiMurill Polysaccharides on Expression of Perilipin in Rats With Type 2 Diabetes Mellitus[J]. Journal of Internal Intensive Medicine, 2011, 17(1): 21-23 |
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| Authors: | YANG Xudong ZHANG Jie CUI Rongjun |
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| Affiliation: | .(Mudanjiang Medical College,Mudanjiang 157011,China ) |
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| Abstract: | Objective：To explore the effect of Agaricus blazeiMurill polysaccharides（ABPS）on insulin resistance（IR）and the expression of Perilipin gene in rats with type 2 diabetes mellitus.Methods：Wistar rats were randomly divided into normal control group（group A）,diabetic model group（group B）,ABPS high dose group（group C）,ABPS median dose group（group D）and ABPS low dose group（group E）.Levels of fasing blood glucose（FBG）,fasing insulin（FINS）and blood lipid were measured after 8 weeks,and expression of Perilipin gene was determined by RT-PCR.Results：Compared with those of model control group,levels of FBG,FINS,TC,TG,LDL-C and FFA in ABPS groups decreased,the mRNA expression of Perilipin increased（P0.05）.Conclusions：ABPS might improve carbohydrate and lipid metabolism disorder and decline IR probably through up-regulating the expression of Perilipin gene. |
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| Keywords: | Agaricus blazeiMurill polysaccharides 2-diabetes mellitus Insulin resistance Lipid Perilipin |
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