| 麦门冬汤合苇茎汤抑制小鼠Lewis肺癌生长的体内实验研究 |
| |
| 作者姓名： | 熊飞 周宗剑 姜淼 陈美娟 |
| |
| 作者单位： | 1.南京中医药大学基础医学院，江苏 南京?210046 |
| |
| 基金项目： | 国家科技部"十一五"科技支撑计划重点项目 |
| |
| 摘 要： | 目的?研究麦门冬汤合苇茎汤（简称金方/JIN）对Lewis肺癌小鼠移植瘤的抑制作用并初步探讨药物作用机制。方法?皮下注射LLC（Lewis lung carcinoma，Lewis肺癌细胞）于C57/BL6小鼠右腋下，观察小鼠生存期、抑瘤率、胸腺指数和肿瘤组织EGFR/Raf/MEK的表达。结果?金方可以显著延长小鼠的生存时间，与对照组相比有显著性差异（P<0.01），金方、DDP组对荷瘤小鼠的抑瘤率分别为35%、89%，金方组胸腺指数明显升高，DDP组胸腺指数明显下降，金方、DDP组的EGFR表达均下降(P<0.05，P<0.01)，而各组Raf和MEK表达无显著性差异。结论?金方可以显著延长荷瘤小鼠的生存期，有一定的抑制肿瘤增长和增强免疫能力的作用，其机制可能与其下调肿瘤组织中EGFR的表达进而影响其下游信号通路的传导相关。
|
| 关 键 词： | 麦门冬汤合苇茎汤 Lewis肺癌 免疫 信号通路 |
| 收稿时间： | 2010/10/11 0:00:00 |
| 修稿时间： | 2011/1/15 0:00:00 |
Study of JIN Formula on inhibiting the Lewis Lung Carcinoma in vivo |
| |
| Authors: | XIONG Fei ZHOU Zong-jian JIANG Miao CHEN Mei-juan HUANG Zhen-zhou TANG Yu-ping DUAN Jin-ao JIANG Ming ZHANG Xu |
| |
| Institution: | XIONG Fei1,ZHOU Zong-jian2,JIANG Miao1,CHEN Mei-juan1,HUANG Zhen-zhou1,TANG Yu-ping3,DUAN Jin-ao3,JIANG Ming4,ZHANG Xu1,3 (1.College of Basic Medicine,Nanjing University of Chinese Medicine,Nanjing,210046,China,2.Gastroenterology of Linfen People's Hospital,Linfen,041000,3.Jiangsu Key Laboratory for TCM Formulae Research,4.Hong Kong Baptist University,Hong Kong,China) |
| |
| Abstract: | OBJECTIVE To investigate the effect of JIN Fang(Maimendong Decoction and Weijing Decoction,are ancient formulae from Golden Chamber,and abbreviated as JIN Fang) on inhibiting Lewis xenografted tumor and the mechanism.METHODS Lewis lung carcinoma cells were inoculated subcutaneously into right axillary of C57 BL /6 mice,and then the following data were observed:the mice survival time,tumor inhibiting rate,thymus index,and the expression of EGFR/Raf/MEK in the tumor tissue.RESULTS JIN could significantly prol... |
| |
| Keywords: | Maimendong Decoction and Weijing Decoction Lewis lung carcinoma immunity signaling pathway |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|
