| 氯乙酸乙酯氟代反应的工艺改进 |
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| 引用本文： | 汪树清,周功亚,万宝坤. 氯乙酸乙酯氟代反应的工艺改进[J]. 沈阳药科大学学报, 1988, 0(3) |
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| 作者姓名： | 汪树清 周功亚 万宝坤 |
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| 作者单位： | 武汉化工学院，武汉化工学院，武汉化工学院 86级制药专业学生，86级制药专业学生 |
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| 摘 要： | 抗肿瘤药5-氟尿嘧啶制备过程中,氟代反应收率为47.8%。为提高氟代反应的竟争性,改变了工艺条件,抑制其副反应,使氟乙酸乙酯的收率提高到63.6—66.7%。
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| 关 键 词： | 反应竞争性 氟乙酸乙酯 氟代反应 |
STUDIES ON SYNTHESIS CONDITION OF FLUORINATION OF ETHYL CHLOROACETATE |
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| Wang Shuqing,Wuhan Institute of Chemical Technology. STUDIES ON SYNTHESIS CONDITION OF FLUORINATION OF ETHYL CHLOROACETATE[J]. Journal of Shenyang Pharmaceutical University, 1988, 0(3) |
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| Authors: | Wang Shuqing Wuhan Institute of Chemical Technology |
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| Abstract: | The yield of the fluorination of ethyl chleroacetate is 47.8% in the preparation of 5-fluo-rouracil. When the reaction conditions are improved, that is, to raise the competitive power ofthe flurorination and to inhibit the side reaction, the yield of the ethyl fluoroacetate increasesto 63.6-66.7%. |
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| Keywords: | Competing property of reaction Ethyl fluoroacetate Fluorination |
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