| Abstract: | Adsorption of diphtheria toxin on immobilized preparations of cell membranes was studies in the presence of gangliosides. A mixture of gangliosides completely suppresses adsorption of the toxin on membranes of cells both sensitive (HeLa cells, macrophages) and resistant (L cells) to its action. Gangliosides treated with neuraminidase are less effective. Immobilized gangliosides effectively adsorb diphtheria toxin in the presence of protective colloid and of the detergent Triton X-100. On the basis of these results gangliosides can be regarded as the receptors of diphtheria toxin.N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 549–551, May, 1978. |
