| 食管鳞癌中ERK及其活化形式蛋白的表达及意义 |
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| 引用本文： | 赵萌,刘月平,刘世正,王小玲.食管鳞癌中ERK及其活化形式蛋白的表达及意义[J].临床与实验病理学杂志,2011,27(11). |
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| 作者姓名： | 赵萌 刘月平 刘世正 王小玲 |
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| 作者单位： | 河北医科大学第四医院病理科,石家庄,050011 |
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| 基金项目： | 河北省强势特色学科资助基金(200552); 河北省卫生厅2009年医学科学研究重点课题计划(20090509,20090485); 河北省自然科学基金(C2009001209) |
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| 摘 要： | 目的研究食管鳞癌及食管黏膜组织中的细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)及其活化形式蛋白(P-ERK)的表达情况,并与食管癌临床病理特征进行相关性分析,探讨ERK及其活化形式蛋白在食管鳞癌发生发展中的作用。方法采用Western blotting法检测食管癌组织与黏膜组织中ERK及P-ERK蛋白的表达情况,并分别从食管鳞癌患者年龄、性别、病理分化程度、临床分期及淋巴结有无转移等方面进行相关性研究。同时,采用免疫组化SP法从食管鳞癌病理分化程度、临床分期及淋巴结有无转移方面进一步检测ERK及P-ERK与食管鳞癌的相关性。结果由Western blotting法结果可以看出,ERK及P-ERK在食管癌组织中表达明显增强,而在食管黏膜组织中则呈低表达,差异均有统计学意义(P<0.01)。ERK在患者的年龄、性别和分化程度各组间的表达差异无显著性(P>0.05),而在临床分期、淋巴结转移各组间差异有显著性(P<0.05),且T3-4期患者ERK及P-ERK蛋白的表达强度明显高于T1-2期患者;食管鳞癌淋巴结发生转移患者ERK及P-ERK蛋白的表达强度明...
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| 关 键 词： | 食管肿瘤 ERK P-ERK |
The role and significance of ERK and its activation in esophageal squamous cell carcinoma |
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| ZHAO Meng,LIU Yue-ping,LIU Shi-zheng,WANG Xiao-ling.The role and significance of ERK and its activation in esophageal squamous cell carcinoma[J].Chinese Journal of Clinical and Experimental Pathology,2011,27(11). |
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| Authors: | ZHAO Meng LIU Yue-ping LIU Shi-zheng WANG Xiao-ling |
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| Institution: | ZHAO Meng,LIU Yue-ping,LIU Shi-zheng,WANG Xiao-ling (Department of Pathology,the Fourth Affiliated Hospital,Hebei Medical University,Shijiazhuang 050011,China) |
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| Abstract: | Purpose To investigate ERK and its activation protein expression in the human esophageal squamous cell carcinoma and esophageal mucous membrane tissue,and to analyze the relationship between the expression of ERK and P-ERK and pathological features of esophageal cancer,and to explore the role and significance of ERK and its activation in development of the human esophageal squamous cell carcinoma.Methods The protein expressions of ERK and P-ERK were detected by Western blotting and immunohistochemical S-P m... |
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| Keywords: | esophageal neoplasm ERK P-ERK |
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