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| 食管鳞状细胞癌中HGF表达与肿瘤血管形成的关系 | |
| 引用本文： | 臧茹琨,宋轶鹏,胡立宽,姜玉华.食管鳞状细胞癌中HGF表达与肿瘤血管形成的关系[J].临床与实验病理学杂志,2011,27(11). |
| 作者姓名： | 臧茹琨 宋轶鹏 胡立宽 姜玉华 |
| 作者单位： | 1. 山东大学医学院、山东大学齐鲁医院肿瘤防治研究中心,济南,250012;烟台毓璜顶医院放疗科,烟台,264000 2. 山东大学医学院、山东大学齐鲁医院肿瘤防治研究中心,济南,250012 3. 山东大学医学院、山东大学齐鲁医院肿瘤防治研究中心,济南,250012;山东大学第二医院肿瘤中心,济南,250033 |
| 摘 要： | 目的研究肝细胞生长因子(hepatocyte growth factor,HGF)在食管鳞癌中的表达及其与肿瘤血管形成之间的关系。方法应用免疫组化PV两步法检测64例食管鳞癌组织及20例癌旁正常组织中HGF及CD34的表达情况,并计数微血管密度(microvessel density,MVD)。结果 HGF在食管鳞癌中的表达(76.6%)高于癌旁正常组织(15.0%,P<0.05),且与肿瘤直径、分化程度及淋巴结转移有关;食管鳞癌组织的MVD值(38.87±17.55)/mm2明显高于癌旁正常组织的MVD值(15.10±3.76)/mm2(P<0.05),肿瘤直径>5 cm,有淋巴结转移及侵袭较深的肿瘤MVD值高(P<0.05);食管鳞癌中HGF阳性组MVD值为(42.25±16.50)/mm2,高于HGF阴性组MVD值(27.89±16.83)/mm2(P=0.005),且MVD值与HGF的表达之间具有相关性。结论 HGF的高表达与食管鳞癌的恶性生物学行为及肿瘤血管生成关系密切,HGF可作为食管鳞癌生物治疗的潜在靶点。 |
| 关 键 词： | 食管肿瘤 肝细胞生长因子 免疫组化 微血管密度 |
Expression of hepatocyte growth factor in esophageal squamous-cell carcinoma and its relationship to tumor angiogenesis |
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| ZANG Ru-kun,SONG Yi-peng,HU Li-kuan,JIANG Yu-hua.Expression of hepatocyte growth factor in esophageal squamous-cell carcinoma and its relationship to tumor angiogenesis[J].Chinese Journal of Clinical and Experimental Pathology,2011,27(11). | |
| Authors: | ZANG Ru-kun SONG Yi-peng HU Li-kuan JIANG Yu-hua |
| Institution: | ZANG Ru-kun1,2,SONG Yi-peng1,HU Li-kuan1,JIANG Yu-hua1,3 (1College of Medicine,Shandong University,Cancer Center,Qilu Hospital of Shandong University,Jinan 250012,China,2Department of Oncology,Yuhuangding Hospital,Yantai 264000,3Cancer Center,the Second Hospital of Shandong University,Jinan 250033,China) |
| Abstract: | Purpose To investigate the expression of hepatocyte growth factor(HGF) in esophageal squamous-cell carcinoma(ESCC) and its relationship to tumor angiogenesis.Methods The expression of HGF and CD34 in 64 specimens of ESCC and 20 cases of adjacent normal tissues were detected using immunohistochemmistry(IHC).The microvessel density(MVD) was calculated.Results Positive rate of HGF protein expression in ESCC was statistically higher than that of adjacent normal tissues(76.6% vs 15.0%,P<0.05).The expression of H... |
| Keywords: | esophageal neoplasms hepatocyte growth factor immunohistochemmistry microvessel density |
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