| 弥漫性大B细胞淋巴瘤中AID蛋白的表达及意义 |
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| 引用本文： | 徐晓,欧阳斌燊,路名芝,刘勇. 弥漫性大B细胞淋巴瘤中AID蛋白的表达及意义[J]. 临床与实验病理学杂志, 2011, 27(12) |
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| 作者姓名： | 徐晓 欧阳斌燊 路名芝 刘勇 |
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| 作者单位： | 1. 江西省九江学院附属医院病理科,九江,332000
2. 江西省人民医院病理科,南昌,330006 |
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| 摘 要： | 目的研究活化诱导胞苷脱氨酶(activation-induced cytidine deaminase,AID)在弥漫性大B细胞淋巴瘤(diffuse large Bcell lymphoma,DLBCL)中的表达,探讨其与DLBCL的临床病理特征、免疫组化亚组及预后的关系。方法采用组织芯片免疫组化法检测101例DLBCL中AID、CD10、BCL-6、MUM1、Ki-67的表达,免疫组化双重染色检测AID与CD20、Ki-67的共定位表达。结果 AID在DLBCL的肿瘤性B细胞中阳性表达率为26.7%。101例DLBCL中,AID阳性表达率在年龄≥60岁患者中明显高于<60岁的患者(P<0.05),AID的表达与患者性别、病变部位、形态学变异型、免疫组化亚组无关(P>0.05)。DLBCL中,AID的表达与B细胞分化标记物CD10、BCL-6和MUM1的表达无相关性(P>0.05),与Ki-67增殖指数(Ki-67>50%)呈正相关(P<0.05)。生存分析表明,AID阳性表达者的5年生存率明显低于AID阴性表达者,两者之间的差异具有统计学意义(P=0.042)。结论 AID的阳性表达与DLBCL的不良预后...
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| 关 键 词： | 淋巴瘤 B细胞 AID蛋白 免疫组化 组织芯片 预后 |
Clinicopathological significance of activation-induced cytidine deaminase expression in diffuse large B cell lymphoma |
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| XU Xiao,OU-YANG Bin-shen,LU Ming-zhi,LIU Yong. Clinicopathological significance of activation-induced cytidine deaminase expression in diffuse large B cell lymphoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2011, 27(12) |
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| Authors: | XU Xiao OU-YANG Bin-shen LU Ming-zhi LIU Yong |
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| Affiliation: | XU Xiao1,OU-YANG Bin-shen1,LU Ming-zhi2,LIU Yong2(1Department of Pathology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China,2Department of Pathology,Jiangxi Provinal People's Hospital,Nanchang 330006,China) |
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| Abstract: | Purpose To investigate the expression of activation-induced cytidine deaminase(AID) in diffuse large B cell lymphoma(DLBCL) and its relationship with clinicopathologic parameters,immunophenotype,and prognosis.Methods Immunohistochemical staining for AID,CD10,BCL6,MUM1 and Ki-67 was performed on paraffin-embedded tissue microarray from 101 cases of DLBCLs.The colocalized expression of AID and CD20,Ki-67 in DLBCL was detected by immunohistochemical double staining method.Results The positive rate of AID expre... |
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| Keywords: | lymphoma B cell AID protein immunohistochemistry tissue microarray prognosis |
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