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| 睡眠剥夺对吗啡成瘾小鼠学习记忆能力的影响 | |
| 引用本文： | 李永红,关俊文,杨波,杨天华. 睡眠剥夺对吗啡成瘾小鼠学习记忆能力的影响[J]. 四川生理科学杂志, 2011, 33(3): 100-102 |
| 作者姓名： | 李永红 关俊文 杨波 杨天华 |
| 作者单位： | 1. 成都信息工程学院电子工程学院,四川,成都,610225 2. 四川大学华西医院神经外科,四川,成都,610041 3. 四川大学华西医院神经内科,四川,成都,610041 |
| 基金项目： | 成都信息工程学院科研基金资助项目，四川省科技支撑计划项目，四川省卫生斤料学研究项目，广东省医孕科研基金 |
| 摘 要： | 目的:观察睡眠剥夺对吗啡成瘾小鼠的空间学习记忆能力的影响。方法:ICR小鼠40只随机分为4组(n=10):生理盐水对照组、吗啡成瘾实验组、生理盐水+睡眠剥夺对照组、吗啡成瘾+睡眠剥夺实验组。小鼠递增注射吗啡7 d建立成瘾模型后,通过睡眠剥夺箱48 h建立睡眠剥夺模型,水迷宫实验观察其学习记忆的前后差异对比。结果:与单纯吗啡成瘾组及睡眠剥夺组相比,吗啡成瘾+睡眠剥夺组与睡眠剥夺小鼠水迷宫逃避潜伏期时间明显延长(P<0.05)。结论:睡眠剥夺加重吗啡成瘾ICR小鼠的学习记忆能力的损害作用。 |
| 关 键 词： | 成瘾 睡眠剥夺 水迷宫 学习记忆 |
Study on the effect of sleep deprivation morphine-addicted ICR mice in learning and memory |
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| Li Yong-hong,Guan Jun-wen,Yang Bo,Yang Tian-hua. Study on the effect of sleep deprivation morphine-addicted ICR mice in learning and memory[J]. Sichuan Journal of Physiological Sciences, 2011, 33(3): 100-102 | |
| Authors: | Li Yong-hong Guan Jun-wen Yang Bo Yang Tian-hua |
| Affiliation: | 1. Department of Electronic Engineering, Chengdu University of Information Technology, Sichuan Chengdu 610225; 2. Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan Chengdu 610041; 3. Department of Neurology, West China Hospital, Sichuan University, Sichuan Chengdu 610041) |
| Abstract: | Objective： To investigate the effects of sleep deprivation on morphine-addicted mice spatial learning and memory ability by water maze. Methods： 40 ICR mice were randomly divided into 4 groups（n=10） ：morphine-addicted group, saline control group, sleep deprivation and morphine-addicted group, sleep deprivation and saline control group. The model of morphine dependent mice was established by gradually increasing the doses of morphine by subcutaneous injection （from 5 mg· kg^-1 to 40 mg· kg^-1 , 5 days）. Experimental model of sleep deprivation was established by use of flow pot method. Learning ability of mice was tested with water maze. Results： Compared with morphine-addicted group, sleep deprivation and saline control group, sleep deprivation and morphine-addicted group displayed much longer water maze escape latency time （P〈0. 05）. Conclusion： Sleep deprivation has an effect on morphine addiction and morphine withdrawal in mice. |
| Keywords: | Addiction Sleep deprivation Water maze Learning and memory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |