Buspirone,gepirone, ipsapirone,and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam |
| |
| Authors: | Jerry B. Richards Karen E. Sabol Timothy H. Hand David C. Jolly Gerard J. Marek Lewis S. Seiden |
| |
| Affiliation: | (1) Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, 60637 Chicago, IL, USA;(2) Present address: Department of Psychology, Oglethorpe University, 4484 Peachtree Road, NE, 30319 Atlanta, GA, USA;(3) Present address: Department of Pharmacodynamics, University of Illinois, 833 South Wood, MC # 865, 60612 Chicago, IL, USA;(4) Present address: Connecticut Mental Health Center, Yale University School of Medicine, Clinical Neuroscience Research, 34 Park Street, 06508 New Haven, CT, USA |
| |
| Abstract: | The effects of four serotonin (5-HT)-1A compounds (buspirone, gepirone, ipsapirone and zalospirone) were compared with 5-hydroxytryptophan (5-HTP) [a 5-HT precursor with antidepressant (AD) efficacy], and diazepam (a benzodiazepine anxiolytic), on a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule. Past research has shown that AD and anxiolytic compounds each have distinct effects on the DRL 72-s interresponse time (IRT) distribution profile. In the present paper, the profile of the IRT distribution was quantitatively characterized by three metrics: burst ratio, peak location and peak area. 5-HTP shifted the IRT distribution peak toward longer IRT durations, increased reinforcement rate and decreased response rate. The profile of the IRT distribution was not disrupted by 5-HTP. Diazepam disrupted the IRT distribution and increased bursting. In general, the arylpiperazine, 5-HT1A compounds increased reinforcement rate, decreased response rate and disrupted the profile of the IRT distribution. The effects of the four arylpiperazine 5-HT1A compounds on the IRT distribution profile were different from the AD profile of 5-HTP and the benzodiazepine anxiolytic profile of diazepam. Disruption of the IRT distribution by buspirone, gepirone, ipsapirone and zalospirone may result from decreased 5-HT transmission mediated by the presynaptic, somatodendritic 5-HT1A receptor. |
| |
| Keywords: | Arylpiperazine Serotonin1A Operant behavior Waiting capacity Antidepressant Anxiolytic Interresponse times |
| 本文献已被 SpringerLink 等数据库收录！ |
|
