精蛋白锌重组赖脯胰岛素混和注射液对初诊糖尿病血糖及胰岛功能的影响

目的探讨精蛋白锌重组赖脯胰岛素混和注射液（优泌乐25）强化治疗对初诊2型糖尿病患者血糖及胰岛功能的影响。方法对60例初诊2型糖尿病患者进行2个月的优泌乐25治疗，观察治疗前后空腹血糖（FPG）及餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数、胰岛素分泌指数、胰岛素敏感指数、空腹胰岛素（FINS）与FPG比值。结果优泌乐25治疗后，FPG、2hPG、HbA1c、胰岛素抵抗指数均较治疗前明显下降（P〈0．01）；空腹C肽的分泌、胰岛素、FINS与FPG比值、胰岛素分泌指数、胰岛素敏感指数均较治疗前明显升高（P〈0．01）。结论优泌乐25强化治疗能显著改善初诊2型糖尿病患者的血糖及胰岛功能。

25 % insulin lispro( Mix 75/25 ) intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabetie patients

Objective To explore the effect of 25% insulin lispro( Mix 75/25) intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabets. Methods Sixty patients with newly diagnosed type 2 diabetes were treated by 2 months 25% insulin lispro(Mix 75/25) treatment. The level of fasting plasma glucose (FPG) ,2 hours postprandial glucose (2hPG), glycosylated hemoglobin A1c (HbA1c), the fasting insulin and Cpeptide, insulin resistance index (HOMA-A), insulin secretion index (HOMA-B), insulin sensitivity index (ISI) and the ratio of fasting insulin to fasting glucose(FINS/FPG) were compared before and after 25% insulin lispro(Mix 75/25) treatment. Results After the treatment,FPG,2hPG,HbA1c and HOMA-A were significantly decreased( all P＜0. 01 ) ;the fasting insulin and C-peptide,FINS/FPG, HOMA-B and ISI greatly increased( all P＜0. 01 ). Conclusion 25% insulin lispro( Mix 75/25) intensive treatment can effectively improve plasma glucose and pancreatic function in newly diagnosed type 2 diabetes.