不稳定性心绞痛与血管活性肽的相关性

目的 :探讨不稳定性心绞痛 （UAP）与血管活性肽的相关性。方法 :观察 42例 UAP患者心绞痛发作前后血浆内皮素 （ET）、降钙素基因相关肽 （CGRP）、神经肽 Y （NPY）及 P物质 （SP）的变化 ,并和 2 0例正常人对照。结果 :当心绞痛发作时 ,UAP患者血浆 ET,NPY,SP均较前明显升高 （P<0 .0 5 ） ,CGRP含量下降 ;随着心绞痛的缓解 ,血浆 CGRP开始升高 ,ET,NPY和 SP均于 3 d后恢复至发作前水平。结论 :U AP的发生与血管活性肽的变化密切相关 ,血管活性肽对维持冠脉舒张和循环有重要意义

The relation of plasma vasoactive peptide concentration with UAP

AIM:To probe into relation beween unstable angina pectoris (UAP) and vasoactive peptide. METHODS:We investigated the variation of plasma concentration of endothelin (ET), calcitonin gene related peptide (CGRP),neuropeptide Y (NPY) and substance P (SP) in 42 patients with UAP and 20 healthy subjects. RESULTS:When angina pectoris attacked ET,NPY,SP increased ( P <0.05). Concentration of CGRP decreased. After angina pectoris was relieved,ET,NPY and SP concentration decreased to pre angina pectoris level in 3 days but CGRP concentration was still high. CONCLUSION:The variation of plasma vasoactive peptide concentration was not only related to UAP attack but also significant to the maintance coronary diastole and corculation.