| P40家族成员及其在自身免疫性疾病中的作用 |
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| 引用本文： | 郭薇,朱玥,罗成,王辰,姚文兵. P40家族成员及其在自身免疫性疾病中的作用[J]. 药物生物技术, 2011, 0(1): 81-84 |
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| 作者姓名： | 郭薇 朱玥 罗成 王辰 姚文兵 |
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| 作者单位： | 中国药科大学生命科学与技术学院分子生物学教研室; |
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| 摘 要： | 作为P40家族中研究最为广泛的细胞因子,白细胞介素-12(Interleukin-12)其最显著的特点是有助于Th1细胞分化,参与由Th1细胞所介导的免疫性疾病。而白细胞介素-23(Interleukin-23)与Th17细胞增殖有关,最新发现Th17介导的免疫反应在实验性变态反应性脑脊髓炎(EAE)和多发性硬化症(MS)疾病方面发挥重要作用,并且其分化途径的提出对传统的Th1/Th2细胞免疫也带来了新的挑战[1]。该家族的另外两个成员P40单体和P40同源二聚体也参与免疫调控,实验证明P40分子不仅在细胞内感染及炎症过程中起着重要的调节作用,而且与银屑病、多发性硬化症、Crohn’s病等多种自身免疫性临床疾病的发病密切相关。
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| 关 键 词： | P40亚基 白细胞介素-12 白细胞介素-23 自身免疫性疾病 |
Role of P40 Family Member in Autoimmune Diseases |
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| GUO Wei,ZHU Yue,LUO Cheng,WANG Chen,YAO Wen-bing. Role of P40 Family Member in Autoimmune Diseases[J]. Pharmaceutical Biotechnology, 2011, 0(1): 81-84 |
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| Authors: | GUO Wei ZHU Yue LUO Cheng WANG Chen YAO Wen-bing |
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| Affiliation: | GUO Wei,ZHU Yue,LUO Cheng,WANG Chen,YAO Wen-bing(Department of Molecular Biology,School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The IL-12,the most widely studied cytokine of this family,is well-characterized for its Th1-favoring activity,and therefore plays a key role in the pathophysiology of Th1-mediated autoimmune diseases.On the other hand,the IL-23,another member of the P40 family with shared P40 subunit,drives polarization of Th17,a subset of T cell suspected to have a key role in the pathophysiology of MS and experimental allergic encephalomyelitis(EAE),poses a challenge to our current understanding of Th1/Th2 hypotheses in a... |
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| Keywords: | P40 subunit IL-12 IL-23 Autoimmune diseases |
| 本文献已被 CNKI 等数据库收录！ |
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