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| 盐酸纳洛酮鼻腔喷雾剂的药效学研究 | |
| 引用本文： | 刘亚琴,林向阳,李万华,孙建绪,张晓燕,高永良. 盐酸纳洛酮鼻腔喷雾剂的药效学研究[J]. 中国药物应用与监测, 2011, 8(1): 15-17 |
| 作者姓名： | 刘亚琴 林向阳 李万华 孙建绪 张晓燕 高永良 |
| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京,100850;国家发展改革委员会药品价格评审中心,北京,100045 2. 空军后勤部卫生部,北京,100720 3. 军事医学科学院毒物药物研究所,北京,100850 |
| 摘 要： | 目的:评价盐酸纳洛酮鼻腔喷雾剂的药效。方法:以新西兰大耳白兔为动物模型,通过给予中毒剂量的盐酸二氢埃托啡建立阿片类药物中毒模型,考察高、中、低三个浓度盐酸纳洛酮鼻腔喷雾剂的药效,并与肌内注射及静脉注射盐酸纳洛酮注射液的救治效果进行比较。结果:盐酸纳洛酮鼻腔喷雾剂治疗效果与肌注相当。结论:盐酸纳洛酮鼻腔喷雾剂起效迅速,救治效果显著,使用方便,特别适合危重症病人的自救与互救。 |
| 关 键 词： | 盐酸纳洛酮 鼻腔喷雾剂 药效学 |
Pharmacodynamic study of nasal spray of naloxone hydrochloride |
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| LIU Ya-qin,LIN Xiang-yang,LI Wan-hua,SUN Jian-xu,ZHANG Xiao-yan,GAO Yong-liang. Pharmacodynamic study of nasal spray of naloxone hydrochloride[J]. , 2011, 8(1): 15-17 | |
| Authors: | LIU Ya-qin LIN Xiang-yang LI Wan-hua SUN Jian-xu ZHANG Xiao-yan GAO Yong-liang |
| Affiliation: | LIU Ya-qin1,2,LIN Xiang-yang3,LI Wan-hua1,SUN Jian-xu1,ZHANG Xiao-yan1,GAO Yong-liang1(1.Institute of Pharmacology and Toxicology,the Academy of Military Medical Sciences,Beijing 100850,China,2.Evaluation Center of Drug Pricing,National Development and Reform Commission,Beijing 100045,3.Ministry of Health,the Air Force Logistics,Beijing 100720,China) |
| Abstract: | Objective:To evaluate pharmacodynamics of nasal spray of naloxone hydrochloride.Methods:The opioids poisoning model was established by injection of toxic dose of dihydroetorphine hydrochloride in rabbit to investigate the pharmacodynamics of nasal spray of naloxone hydrochloride in different concentrations,and the pharmacodynamics of naloxone hydrochloride was evaluated after intranasal,intramuscular and intravenous administration.Results:Treatment effectiveness of naloxone hydrochloride after intranasal ad... |
| Keywords: | Naloxone hydrochloride Nasal spray Pharmacodynamics |
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