醛固酮合成酶基因CYP11B2(-344T/C)多态性对北京汉族人群高血压患者缬沙坦降压疗效的影响

目的探讨醛固酮合成酶基因CYP11B2(-344T/C)多态性与北京汉族人原发性高血压的关系及对缬沙坦降压疗效的影响。方法采用多聚酶链式反应结合限制性内切酶片段长度多态性分析方法检测1999年8月至2003年10月首都医科大学宣武医院345例原发性高血压(EH)患者和156名健康人(NE)醛固酮合成酶基因CYP11B2(-344T/C)多态性。并测定各组人群的诊室血压、24h血压以及各项生化指标。其中98例高血压患者给予缬沙坦80mg,每日1次,用药4周,测定用药前后的血压指标。结果EH组CC CT基因型频率显著高于NE组;EH组C等位基因频率显著高于NE组(P<0.01)。CC CT基因型用药后的收缩压下降值、舒张压下降值、平均动脉压下降值及24h收缩压下降值、24h舒张压下降值、24h平均动脉压下降值均显著大于TT基因型(P<0.05)。结论醛固酮合成酶基因CYP11B2(-344T/C)多态性与北京汉族人原发性高血压明显相关,并且可能是缬沙坦降压疗效的有效预测因子。

Influence of gene polymorphism of aldosterone synthese gene CYP11 B2 (-344T/C) on antihypertensive response to Valsartan in Han nationality essential hypertension patients in Beijing.

Objective To evaluate the association between gene polymorphism of aldosterone synthese gene CYP11B2(-344T/C)and essential hypertension and to observe the antihypertensive response to Valsartan in Han nationality in Beijing.Methods Polymerase chain reaction was used to detect the polymorphism of aldosterone synthese gene CYP11B2(-344T/C)in 345 hypertensive patients(EH)and 157 normotensive controls(NE)from Aug.1999 to Oct.2003.Clinical blood pressure and biochemical index were also detected.Blood pressure was repeated in 98 patients with Valsartan treatment for 4 weeks.Results The frequencies of CC CT genotype of aldosterone synthese gene CYP11B2(-344T/C)polymorphism among EH was significantly higher than that among NE(P<0.05);the C allele of CYP11B2(-344T/C)polymorphism among EH was significantly higher than that among NE(P<0.01).The descending values of SBP,DBP,MAP,24 hSBP,24 hDBP,24 hMAP of CC CT genotype of CYP11B2(-344T/C)polymorphism were significantly higher than TT genotype(P<0.05).Conclusion There is significant association between CYP11B2(-344T/C)polymorphism and essential hypertension in Han nationality in Beijing.CYP11B2(-344T/C)polymorphism is a predictor of antihypertensive effect of Valsartan.