| 散发性直肠癌微卫星不稳定性与临床及病理特征的关系 |
| |
| 引用本文： | 杨刚,钟天,陈蔚云,周玮,朱荣涛. 散发性直肠癌微卫星不稳定性与临床及病理特征的关系[J]. 江西医学院学报, 2008, 48(2): 60-64 |
| |
| 作者姓名： | 杨刚 钟天 陈蔚云 周玮 朱荣涛 |
| |
| 作者单位： | [1]南昌大学第二附属医院胃肠外科 [2]南昌大学医学院功能中心 [3]江西中医学院成教学院招生科,南昌 330006 [4]江西省肿瘤医院头颈外科,南昌 330029 [5]河南大学第一附属医院普外科,河南开封 475000 |
| |
| 摘 要： | 目的探讨散发性直肠癌临床、病理特征与微卫星不稳定性（Microsatellite instability，MSI）表达之间的关系。方法检测75例散发性直肠癌手术标本DNA中5个位点的MSI表达，分析其表达与不同临床和病理特症之间的关系。结果正常结／直肠组织中无MSI阳性位点的表达。直肠癌组织中MSI-H（≥2个位点出现阳性）表达略为20．O％；MSI表达与性别、发现的淋巴结个数及阳性淋巴结个数、远处转移无明显关系；位于直肠上部的癌肿MSI高于位于下部者（P〈O．05）；位于直肠后半部的癌肿MSI高于位于直肠前半部者，但两者之间没有统计学差异；癌肿的左右、上下径，浸润深度与MSFH表达成反向关系；虽然有MSFH表达在患者年龄、癌肿在直肠的不同象限、非连续性扩散方面有增加，但无统计学差异。结论MSI表达对直肠癌预后的判定有一定的辅助价值，可作为TNM分期的一个补充，亦可作为判定高危直肠癌的参考指标之一，但与常规病理指标相比还有一些无法解释的矛盾现象，还需行前瞻性、随机性、大样本深入研究。
|
| 关 键 词： | 散发性直肠癌 微卫星不稳定性 预后 分期 |
| 文章编号： | 1000-2294(2008)02-0060-04 |
| 修稿时间： | 2007-07-03 |
The Relation of Microsatellite Instability Expression and Clinical Pathological Feature in Sporadic Rectal Cancer |
| |
| YANG Ganga,ZHONG Tian,CHEN Wei-yunb,ZHOU Wei,ZHU Rong-tao. The Relation of Microsatellite Instability Expression and Clinical Pathological Feature in Sporadic Rectal Cancer[J]. Acta Academiae Medicinae Jiangxi, 2008, 48(2): 60-64 |
| |
| Authors: | YANG Ganga ZHONG Tian CHEN Wei-yunb ZHOU Wei ZHU Rong-tao |
| |
| Affiliation: | YANG Gang1a,ZHONG Tian2,CHEN Wei-yun1b,ZHOU Wei3,ZHU Rong-tao4(1a.Department of Gastrointestine Surgery,the Second Affiliated Hospital,1b.Functional Center of Medical College,Nanchang University,2.Recruitment Office of AdultEducation College,Jiangxi Traditional Chinese Medicine College,Nanchang 330006,China,3.Department of Head , Neck Surgery,Jiangxi Oncological Hospital,Nanchang330009,4.Department of General Surgery,the First Affiliated Hopsital of He'nan University,Kaifeng 475000,China) |
| |
| Abstract: | Objective To evaluate the relationship of MSI expression and clinical-pathological parameters in the prognosis of sporadic rectal cancer.Methods The operative specimen of 75 sporadic rectal cancer and corresponding normal tissues were analyzed for MSI by testing five microsatellite markers.The clinical and pathological feature were also collected for analysis.ResultsThere were no MSI positive express in normal colon/rectal specimen.The MSI expression in cancer specimen was little higher than the reports fro... |
| |
| Keywords: | sporadic rectal cancer microsatellite instability prognosis stage |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
