| 光量子液疗对大鼠脑缺血再灌注损伤后炎症反应的影响 |
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| 引用本文： | 许予明,宋波,秦洁,阎福岭. 光量子液疗对大鼠脑缺血再灌注损伤后炎症反应的影响[J]. 郑州大学学报(医学版), 2004, 39(5): 807-809 |
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| 作者姓名： | 许予明 宋波 秦洁 阎福岭 |
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| 作者单位： | 郑州大学第一附属医院神经内科,郑州,450052;东南大学附属中大医院神经内科,南京,210000 |
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| 基金项目： | 河南省卫生厅创新人才基金资助项目 2 0 0 3 0 2 4 |
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| 摘 要： | 目的 :研究光量子液疗治疗脑缺血再灌注损伤的作用及机制。方法 :雄性SD大鼠 12 0只 ,随机分为假手术组、手术组、生理盐水治疗组和光量子液疗组 ,各组分别于缺血 1h再灌注 3h、6h、12h、2 4h、4 8h处死动物 ,断头取脑 ,采用ELISA检测大鼠脑组织匀浆中细胞间粘附分子 1(ICAM 1)、巨噬细胞炎性蛋白 1(MIP 1)的表达。结果 :手术组、生理盐水治疗组和光量子液疗组各时间点ICAM 1、MIP 1均高于假手术组 (P <0 .0 1)。光量子液疗组各时间点ICAM 1、MIP 1的表达显著低于手术组和生理盐水治疗组 (P <0 .0 5 )。结论 :减轻炎症细胞对缺血区脑组织的浸润 ,可能是光量子液疗脑保护的作用机制之一。
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| 关 键 词： | 脑缺血再灌注损伤 炎症 细胞间黏附因子-1 巨噬细胞炎性蛋白-1 光量子液疗 大鼠 |
| 修稿时间： | 2004-04-18 |
Effect of ultraviolet liquid irradiation on inflammation induced by cerebral ischemia-reperfusion in rats |
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| XU Yuming ),SONG Bo ),QIN Jie ),YAN Fuling ) ). Effect of ultraviolet liquid irradiation on inflammation induced by cerebral ischemia-reperfusion in rats[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(5): 807-809 |
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| Authors: | XU Yuming ) SONG Bo ) QIN Jie ) YAN Fuling ) ) |
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| Affiliation: | XU Yuming 1),SONG Bo 1),QIN Jie 1),YAN Fuling 2) 1) Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Neurology,Zhongda Hospital of Dongnan University,Nanjing 210000 |
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| Abstract: | Aim: To study the effect of ultraviolet liquid irradiation on PMNs infiltration after cerebral ischemia/reperfusion (I/R) injury in rats. Methods: A total of 120 male SD rats were randomly divided into sham-operated group, operated group, physiological saline treatment group, and ultraviolet liquid irradiation treatment group with 30 rats in each group. Each group was separated into I/R 3 h, 6 h, 12 h, 24 h, 48 h five subgroup. Rats' brains were prepared to homogenate in order to examine ICAM-1 and MIP-1 with ELISA method. Results: Compared to the other three groups, the expressions of ICAM-1 and MIP-1 in ultraviolet liquid irradiation treatment group were decreased (P< 0.05). Conclusion: Ultraviolet liquid irradiation can protect rat from cerebral ischemic/reperfusion injury by reducing inflammatory responding. |
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| Keywords: | cerebral ischemia/reperfusion inflammation intercellular adhesion molecule-1 (ICAM-1) macrophage inflammation protein-1 (MIP-1) ultraviolet liquid irradiation rat |
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