Insulin resistance in chronic hepatitis B and C. |
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| Authors: | Amir Houshang Mohammad Alizadeh Farahnaz Fallahian Seyed Moayed Alavian Mitra Ranjbar Mehdi Hedayati Farzaneh Rahimi Hossein Khedmat Arash Etemadi Mohammad Reza Zali Fereidoun Azizi |
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| Affiliation: | Research Center of Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ahmaliver@yahoo.com |
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| Abstract: | AIM: To determine whether insulin resistance occurs in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC) and its relationship with the presence of liver fibrosis and steatosis. METHODS: Untreated patients with CHC (n=60) or CHB (n=40), similar in age, gender, body mass index and waist-hip ratio, were studied. Relationship between anthropometric, biochemical (fasting serum insulin, C-peptide, ferritin, iron, TNF-alpha, cholesterol, triglyceride, bilirubin, hemoglobin and platelet concentrations) and liver biopsy (43 CHC and 20 CHB patients) findings was investigated by insulin resistance determined via the homeostasis model assessment (HOMA-IR). RESULTS: The mean fasting serum insulin was 14.9 (11.9) mU/mL in CHC and 21.4 (17.4) in the CHB group (normal range 0.7-9; p=0.049) and mean HOMA-IR was 3.1 (2.6) in CHC versus 4.7 (4.1) in the CHB group (normal range 0.12-4.61; p=0.036). HOMA-IR was significantly associated with fibrosis stage in the CHC group (p=0.015), but not in the CHB group. CONCLUSION: Hyperinsulinemia occurs in chronic viral hepatitis B and hepatitis C; insulin resistance is associated with stage of fibrosis in hepatitis C. |
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