| 胆宁片对胆囊胆固醇结石的防治作用 |
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| 引用本文： | 李可为,季福,王如然,姜皓,施维锦.胆宁片对胆囊胆固醇结石的防治作用[J].肝胆胰外科杂志,2004,16(1):44-46. |
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| 作者姓名： | 李可为 季福 王如然 姜皓 施维锦 |
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| 作者单位： | 上海市第二医科大学附属仁济医院,上海,200001;上海市第二医科大学附属仁济医院,上海,200001;上海市第二医科大学附属仁济医院,上海,200001;上海市第二医科大学附属仁济医院,上海,200001;上海市第二医科大学附属仁济医院,上海,200001 |
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| 摘 要： | 目的：研究胆宁片对胆囊胆固醇结石有无防治作用并初步探讨其机制。方法：豚鼠120只随机均分为4组：胆宁片组建立胆囊胆固醇结石模型后给予胆宁片，同时与熊去氧胆酸(UDCA)组及空白组、致石组对照，测定血、胆汁生化及肝、胆囊病理。结果：胆宁片组成石率为17％显著低于致石组的73％．其致石指数(LI)及血甘油三酯(TG)与肝脂肪变性显著低于致石组。结论：胆宁片对胆囊胆固醇结石有良好的防治作用并可缓解肝脂肪变性。
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| 关 键 词： | 胆囊胆固醇结石 胆宁片 治疗 |
| 文章编号： | 1007-1954(2004)01-0044-03 |
| 修稿时间： | 2004年2月10日 |
Pereventive effect and mechanism of danning tablet on the cholesterol gallstone |
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| LI Ke-wei,JI Fu,WANG Ru-ran,et al..Pereventive effect and mechanism of danning tablet on the cholesterol gallstone[J].Journal of Hepatopancreatobiliary Surgery,2004,16(1):44-46. |
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| Authors: | LI Ke-wei JI Fu WANG Ru-ran |
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| Institution: | LI Ke-wei,JI Fu,WANG Ru-ran,et al. Department of General Surgery,Renji Hospital Affiliated to the Second Medical University of Shanghai,Shanghai 200001 |
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| Abstract: | Objective:To investigate whether danning tablet has the preventive effect on the cholesterol gallstones.Methods:One hundred and twenty guinea pigs were randomly divided into four groups. Danning tablet was given to the danning group after the cholesterol gallstone model has been established. At the same time,the danning group was compared with the other three group for measing serum and bile biochemistry parameters and observing the pathological change of the liver and gallbladder.Results:The incidence of danning group(17%) was significantly lower than that of the model group(73%),and the LI,serum TG and the hepatic steatosis had the similar outcome.Conclusion:Danning tablet can prevent the formation of the cholesterol gallstone and relieve the hepatic steatosis. |
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| Keywords: | cholesterol gallstone danning tablet therapy |
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