SIRT1与血管性疾病的研究进展

沉默信息调节因子2相关酶1 (SIRT1)是一种高度保守的NAD+依赖的第Ⅲ类组蛋白去乙酰化酶,主要通过翻译后修饰调节DNA损伤修复、氧化应激、炎症、细胞衰老、凋亡与增殖等,从而参与血管性疾病的发生发展.因此,SIRT1可能成为治疗血管性疾病的潜在靶点.本文主要对SIRT1的主要生理作用及其在动脉粥样硬化、高血压、肺动脉高压、糖尿病肾病及糖尿病视网膜病变等常见血管性疾病中的作用作一综述.

Progress of SIRT1 in vascular diseases

Silent mating type information regulation 2 homolog-1 (SIRT1) is a highly conserved nicotinamide adenine dinucleotide (NAD)+-dependent class Ⅲ histone deacetylase,which can regulates DNA damage repair,oxidative stress,inflammation,cell senescence,apoptosis and proliferation via posttranslational modification of histone and non-histone proteins and is involved in the pathogenesis of vascular diseases.Therefore,SIRT1 may become a novel therapeutic target for vascular diseases.In this review,we summarized the current knowledge on the physiological functions of SIRT1 and its roles in atherosclerosis,hypertension,pulmonary hypertension,diabetic nephropathy and diabetic retinopathy.