鱼油对ARDS患者预后影响的Meta分析

目的：评价鱼油对 ARDS 患者预后的影响。方法计算机及手工检索 PubMed、Embase、Cochrane图书馆临床随机对照试验资料库、Highwire、中国生物医学文献数据库、中国学术期刊全文数据库(CNKI)、万方数据库,并在互联网检索正在进行的试验：Current Controlled Trial (www.controlled-trials.com)和美国国立卫生研究院临床试验数据库(www.clinicaltrials.gov)。按Cochrane系统评价的方法,选择试验、评价质量,使用 Review Manager 5.2软件进行 Meta 分析。结果共纳入7项随机对照临床试验,包括994例研究对象。与非鱼油添加组相比：鱼油未能降低ARDS患者28 d病死率(RR =0.81,95%CI ：0.56~1.18,P =0.27)；鱼油未能减少 ARDS 患者28 d机械通气时间(WMD=-2.06,95%CI ：-4.81~0.70,P=0.14)；鱼油缩短 ARDS患者28 d内 ICU住院天数,且差异具有统计学意义(WMD=-2.47,95%CI ：-4.33~-0.60,P=0.009)。结论对于 ARDS患者,鱼油的摄入并不能降低病死率及缩短机械通气时间,但有助于减少 ICU 住院时间。

Effects of fish oil on patients with acute respiratory distress syndrome:a meta-analysis

Objective To evaluate the contribution of fish oil in patients with acute respiratory distress syndrome (ARDS).Methods The PubMed,Embase,Cochrane Clinical Trials Register, Highwire,CBM,CNKI,WanFang databases and Current Controlled Trial (www.controlled-trials.com), the U.S.National Institute of Health Clinical Trials(www.clinicaltrials.gov)databases were searched.All related data were extracted.Meta-analysis was conducted using the statistical software Review Manager 5 .2 on the basis of strict quality evaluation,the methods recommended by the Cochrane Collaboration. Results Seven randomized controlled studies (n=994) were included in this meta-analysis.Compared with the non-fish oil group,28-day mortality was not decreased in the fish oil group(RR=0.81,95%CI :0.56-1.18,P=0.27),the time of mechanical ventilation was not decreased in the fish oil group(WMD=-2.06,95%CI :-4.81-0.70,P =0.14),ICU stay time was significantly lower in the fish oil group (WMD=-2.47,95%CI :-4.33--0.60,P=0.009).Conclusions For patients with ARDS,fish oil is non-beneficial in improving the survival and decreasing the time of mechanical ventiation,but can reduce ICU stay time.