慢性阻塞性肺疾病患者骨代谢研究进展

COPD是一种以气流持续受限为特征的慢性呼吸系统疾病,其患病率、致残率、病死率高.骨质疏松是以骨量减少、骨结构退化和骨折风险增加的骨代谢性疾病,是COPD的重要合并症之一,但在临床中常被忽视.当COPD合并骨折时,可引起患者肺功能下降、急性加重频率及病死率增加,因此及早诊治COPD合并的骨质疏松能有效预防骨折的发生,改善患者预后.因此,早期发现、早期诊治骨质疏松,预防骨质疏松相关的骨折对于COPD患者具有重要意义.

The research progress of bone metabolism in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease characterized by persistent airflow limitation.It has a high prevalence and mortality.Besides pulmonary component,significant extra-pulmonary effects are to be considered,including osteoporosis (OP).OP is characterized by a decreased bone mineral density and/or changes of the micro-architectural,resulting in an increased fragility of bones with an increased fracture risk as consequence.When COPD complicate with fracture,the patients' lung function tend to be decline while acute exacerbation frequency and mortality can be increase.Therefore,it is significant for prevent OP in COPD patients.