大鼠严重烧伤后胃,十二指肠粘膜的扫描电镜观察

扫描电镜观察结果显示,两致伤组胃和十二指肠粘膜损害分为水肿、轻度坏死和重度坏死三型。胃粘膜轻度坏死,伤后早期较重,中间轻,后期加重的“马鞍状”。重度者发生较晚,见于24和72 h。十二指肠绒毛,伤后立即水肿伴轻度坏死,2 h重度坏死,24 h达高峰,72 h略减轻。十二指肠粘膜损害发生早、持续时间长、发病率高、程度严重。磷烧伤组胃肠改变较凝固汽油严重。主要原因是热应激反应及磷元素和磷自由基的毒作用;磷自由基较磷元素本身毒性更大。

Ultrastructural changes of gastroduodenal mucosa after severe burns in rats

The changes of the gastroduodenal mucosa after severe hums were observed with scanning electron microscopy in rats.It was found that burn damages on the gastroduodenal mucosa could be distinguished into 3 categories; edema,mild necrosis and severe necrosis.The mild necrosis of the gastric mucosa was quite severe in the early stage postburn,was alleviated in the middle stage and became aggravated in the late stage.The onset of severe necrosis of the gastric mucosa was rather late > usually in the 24th to 72nd h postburn.There was edema associated with mild necrosis of the duodenal mucosa immediately after burns.Severe necrosis occurred in the 2nd h postburn.The manifestations reached the peak in the 24th h and were alleviated in the 72nd h postburn.As a rule,the damages on the duodenal mucosa occurred early and persisted for a long period with high incidence and severe wounding conditions.The damages of gastroduodenal mucosa were more severe in the phosphorus burn group than in the napalm burn proup mainly because of the more intense heat stress after phosphorus burns and the tosicity of the element phosphorus and phosphorus free redicals.