Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice |
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Authors: | Matsugo S Kitagawa T Minami S Esashi Y Oomura Y Tokumaru S Kojo S Matsushima K Sasaki K |
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Affiliation: | Department of Chemical and Biochemical Engineering and CREST, Faculty of Engineering, Toyama University, Japan. |
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Abstract: | The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8. |
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