| IL-24基因与肿瘤免疫治疗 |
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| 引用本文： | 何涛君,肖建华. IL-24基因与肿瘤免疫治疗[J]. 国外医学(肿瘤学分册), 2006, 0(9) |
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| 作者姓名： | 何涛君 肖建华 |
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| 作者单位： | 湖南南华大学病原生物学研究所，湖南南华大学病原生物学研究所 |
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| 摘 要： | 白细胞介素-24(IL-24)又称为黑色素瘤分化相关基因-7(MDA-7),它主要由CD3+ T淋巴细胞和单核细胞表达,为分泌蛋白,由206个氨基酸组成,属于IL-10家族成员。IL-24是第1个被报道的具有白介素作用的肿瘤抑制分子,具有选择性的广谱抗肿瘤活性。IL-24基因通过抑制血管形成、激活生长抑制和DNA损伤基因(GADD)等信号传导途径,抑制肿瘤细胞生长和促进肿瘤细胞凋亡,而对正常细胞无明显影响。INGN241是一种新开发的基因治疗制剂,对多种肿瘤具有抑制和治疗作用。
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| 关 键 词： | 白细胞介素类 免疫疗法 肿瘤 |
IL-24gene and tumor immunotherapy |
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| HE Tao-jun. Institute Pathogenic Biology,Nanhua University,Hunan ,China. IL-24gene and tumor immunotherapy[J]. Foreign Medical Sciences (Cancer Section), 2006, 0(9) |
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| Authors: | HE Tao-jun. Institute Pathogenic Biology Nanhua University Hunan China |
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| Affiliation: | HE Tao-jun. Institute Pathogenic Biology,Nanhua University,Hunan 421001,China |
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| Abstract: | Interleukin-24 (IL-24) is also called melanoma differentiation associated gene-7 (MDA-7). Interleukin-24 expression is restricted to CD3 +T lymphocytes and raonocytes. It is a secretion protein which is composed of 206 amino acid. IL-24 is a member of the IL-10 cytokine family. It is originally identified as a tumor suppressor molecule and has selective broad-spectrum antitumor activity. IL-24 gene causes tumor cells growth suppression and apoptosis by anti-angiogenic activity and activated GADD signal transduction passway. But it has no conspicuous effect on normal cells. INGN241 is a new development preparation on gene treatment. It has growth inhibitory and curative effect towards diverse human tumor cells. |
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| Keywords: | Interleukins Immunotherapy Neoplasms |
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