胸腺肽α1治疗老年慢性阻塞性肺病急性发作期的疗效观察

目的探讨胸腺肽α1治疗老年慢性阻塞性肺病(COPD)急性发作期的疗效。方法将54例老年COPD急性期住院患者随机分为常规治疗组和胸腺肽治疗组2组,胸腺肽治疗组在常规治疗组基础上加用胸腺肽α11.6mg皮下注射,1次/d,疗程2周。观察2组患者血清C反应蛋白(CRP)和降钙素原(PCT)水平、细胞免疫功能水平和临床疗效。结果治疗后胸腺肽组CD3+、CD4+、CD4+/CD8+水平较常规组明显改善(P<0.05),CRP和PCT水平较常规组明显下降(P<0.05),临床有效率较常规组明显提高(P<0.05)。结论胸腺肽α1能改善老年COPD患者的免疫功能,联合胸腺肽α1治疗老年COPD急性发作期效果明显。

The curative effect of the thymosin alpha 1 in elderly chronic obstructive pulmonary disease during acute period

Objective To study the curative effect of the thymosin alpha 1 in elderly chronic obstructive pulmonary disease(COPD)during acute period.Methods 54 elderly inpatients with COPD during acute period were divided into two groups randomly:conventional therapy group and thymosin alpha 1 therapy group.Both two groups were treated with routine method,but the patients of the thymosin alpha 1 therapy group received 1.6mg thymosin alpha 1 through subcutaneous injection qd for 2 weeks,to observe serum C-reactive protein(CRP)and procalcitonin(PCT),cellular immune function and therapeutic effect.Results CD3+,CD4+,CD4+/CD8+of the thymosin alpha 1 therapy group were improved significantly and better than conventional therapy group(P<0.05),CRP and PCT were obviously decreased(P<0.05),the clinical effective rate was higher(P<0.05).Conclusion Thymosin alpha 1 is of great benefit to immune function of elderly COPD patients.The therapeutic effect of combination with thymosin alpha 1 therapy in elderly COPD patients during acute period is obvious.