| 乳酸环丙沙星耳用凝胶的制备及含量测定 |
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| 引用本文： | 胡筱梅,李荫桂,瞿京红. 乳酸环丙沙星耳用凝胶的制备及含量测定[J]. 儿科药学杂志, 2012, 18(11): 40-42 |
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| 作者姓名： | 胡筱梅 李荫桂 瞿京红 |
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| 作者单位： | 湖北医药学院附属东风医院,湖北十堰,442008 |
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| 摘 要： | 目的:制备乳酸环丙沙星耳用凝胶并建立其质量控制方法.方法:采用卡波姆940及CMC-Na为凝胶基质制备乳酸环丙沙星耳用凝胶,采用毛细管电泳法测定乳酸环丙沙星含量.结果:在一定条件下,乳酸环丙沙星与氢化可的松在20 min内能很好分离,线性范围为0.05～ 1.06 mg/mL,r=0.9998,平均加样回收率为96.9％.结论:该制剂工艺合理,简单可行,质量可控,能满足临床用药需求.
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| 关 键 词： | 乳酸环丙沙星 耳用凝胶 质量控制 毛细管电泳法 |
Preparation and Quality Control of Ciprofloxacin Lactate Ear Gel |
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| Hu Xiaomei , Li Yingui , Qu Jinghong. Preparation and Quality Control of Ciprofloxacin Lactate Ear Gel[J]. Journal of Pediatric Pharmacy, 2012, 18(11): 40-42 |
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| Authors: | Hu Xiaomei Li Yingui Qu Jinghong |
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| Affiliation: | (Dongfeng Hospital of Hubei Medical University,Hubei Shiyan 442008,China) |
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| Abstract: | Objective:To prepare ciprofloxacin lactate ear gel and to control the quality of the gel.Methods:The carbopol and CMC-Na were selected for the preparation of this gel.Ciprofloxacin lactate was determinate by HPCE.Results:Ciprofloxacin lactate was successfully separated within 20 minutes,the linear response range was 0.05～1.06 mg/mL,r=0.9998.The average recovery rate was 96.9%.Conclusions:The preparation technique of ciprofloxacin lactate ear gel is reasonable,simple,the quality can be controlled and the quality control method is accurate and fast. |
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| Keywords: | Ciprofloxacin lactate Ear gel Quality control HPCE |
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