| 灯盏花素鼻用微乳凝胶剂的鼻纤毛毒性研究 |
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| 引用本文： | 姚娜,黄庆德,胡建萍,陈雪. 灯盏花素鼻用微乳凝胶剂的鼻纤毛毒性研究[J]. 中医临床研究, 2014, 0(16): 19-20 |
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| 作者姓名： | 姚娜 黄庆德 胡建萍 陈雪 |
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| 作者单位： | 福建中医药大学药学院; |
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| 基金项目： | 福建省科技计划重点项目(2012Y0042);福建省教育厅A类科技项目(JA11130);福建省科技计划项目(2010Y2004) |
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| 摘 要： | 目的：研究灯盏花素鼻用微乳凝胶剂对鼻腔纤毛运动的影响。方法：采用在体蟾蜍上颚模型法，给予自制的灯盏花素鼻用微乳凝胶剂，记录纤毛持续摆动时间，并于显微镜下观察纤毛形态学改变。结果：灯盏花素鼻用微乳凝胶剂对鼻腔纤毛运动无明显影响，相对于NS，纤毛持续摆动时间的相对百分率为93.8%。结论：灯盏花素鼻用微乳凝胶剂无明显鼻腔纤毛毒性，可以用于鼻腔给药。
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| 关 键 词： | 灯盏花素 微乳凝胶剂 鼻用 纤毛毒性 |
A study on the ciliotoxicity of breviscapine microemulsion-based nasal gels |
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| Abstract: | Objective： To study the ciliotoxicity of breviscapine microemulsion-based nasal gels. Methods： The lasting time of ciliary movement was determined and the ciliary morphology was observed with microscope after administration in situ toad palate mode. Results：Breviscapine microemulsion-based nasal gels had no significant effect on ciliary movement. The relative percentage of the lasting time of ciliary movement with physiological was 93.8%. Conclusion：In this study the breviscapine microemulsion-basednasal gels has no significant ciliotoxicity and it can be used for intranasal administration. |
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| Keywords: | Breviscapine Microemulsion-based gel Nasal Ciliotoxicity |
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