Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor |
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| Authors: | M Alvarez-Mon A de la Hera M L Gaspar A Orfao J Casas J Jordá A Durantez |
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| Affiliation: | Departamento de Medicina, Universidad de Alcalá de Henares, Espa?a. |
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| Abstract: | B cell activation was studied in B cells from B cell chronic lymphocytic leukemia (B-CLL) patients. After in vitro stimulation, these B cells showed extensive proliferation in the presence of high-molecular-weight B cell growth factor (BCGF). In contrast, this effect was not observed upon addition of recombinant interleukin-2 (IL-2). In agreement, upon stimulation, B cells expressed Bac-1 antigen but failed to acquire the IL-2 receptor. These results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients. |
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