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左旋卡尼汀对维持性血液透析患者微炎症、贫血和心功能的影响
引用本文:何承荣,刘一李,钟洁莲. 左旋卡尼汀对维持性血液透析患者微炎症、贫血和心功能的影响[J]. 赣南医学院学报, 2008, 28(2): 170-172
作者姓名:何承荣  刘一李  钟洁莲
作者单位:广东省东莞市虎门医院,广东东莞,523911;广东省东莞市虎门医院,广东东莞,523911;广东省东莞市虎门医院,广东东莞,523911
摘    要:目的:观察左旋卡尼汀对维持性血液透析(MHD)患者微炎症、贫血和心功能的影响,探讨左旋卡尼汀对MHD患者的治疗作用。方法:选择已排除急性感染及其他活动性疾病、透析龄超过6个月的MHD患者42例,随机分为治疗组(22例)和对照组(20例)。每次透析结束后,治疗组给予静脉注射左旋卡尼汀2g,对照纽注射等量的生理盐水。观察治疗前及治疗4个月后患者炎症介质、营养状况、贫血和心脏结构与心功能。结果:与治疗前相比,治疗组的超敏C反应蛋白(Hs.CRP)、白介素(IL-6)显著下降,血红蛋白(Hb)、红细胞压积(Hct)显著升高,左心室收缩末内径(LVDs),左心室射血分数(LVEF)明显改善;与对照组比较,治疗组的Hs-CRP、IL-6、Hb、Hct、LVDs、左心室舒张末内径(LVDd)、LVEF差异显著。结论:左旋卡尼汀可改善MHD微炎症状态、贫血和心功能,可作为MHD患者的一种长期治疗药物。

关 键 词:血液透析  微炎症  心力衰竭  左旋卡尼汀
文章编号:1001-5779(2008)02-0170-03
修稿时间:2008-01-28

Effect of L-carnitine on Microinflammatory and anemia and heart function in Maintenance Hemodialysis Patients
HE Cheng-rong,LIU Yi-li,ZHONG Jie-lian. Effect of L-carnitine on Microinflammatory and anemia and heart function in Maintenance Hemodialysis Patients[J]. Journal of Gannan Medical College, 2008, 28(2): 170-172
Authors:HE Cheng-rong  LIU Yi-li  ZHONG Jie-lian
Affiliation:HE Cheng-rong,LIU Yi-li,ZHONG Jie-lian (Dong Guan Humen Hospital,Dongguan Guangdong 523911)
Abstract:Objeclive:To evaluate the effects of L-carnitine on microinflammatory and anemia and heart function in maintenance hemodialysis(MHD) patients.Methods:Forty-two MHD patients were divided into two groups,treatment group(n=22) and control group(n=20),who had undergone hemodialysis for at least six months before the study and were in a stable clinic status without signs of infection or disease activity.In the treatment group 2g of L-carnitine was infused to the patient at the end of each dialysis treatment for ...
Keywords:Hemodialysis  Microinflammatory  Heart failure  L-carnitine  
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