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2004~2009年临床分离肺炎链球菌的血清型/群分布及耐药性监测
引用本文:张雪华. 2004~2009年临床分离肺炎链球菌的血清型/群分布及耐药性监测[J]. 中国当代医药, 2011, 18(8): 9-11
作者姓名:张雪华
作者单位:湖南省益阳市中心医院药剂科,湖南益阳,413000
摘    要:目的:了解当前本院临床分离肺炎链球菌的血清型/群分布及耐药趋势,为临床合理使用抗生素提供参考。方法:以2004~2009年临床分离的822株肺炎链球菌为研究对象,采用荚膜肿胀试验进行血清分型/群,E-test检测菌种对青霉素、头孢呋辛、头孢地尼、头孢克罗、红霉素、四环素、左氧氟沙星、万古霉素等8种抗生素的敏感性。结果:2004年青霉素不敏感肺炎链球菌(PNSP)的分离率为49.4%,并呈逐年上升趋势,至2006年PNSP分离率高达67.8%,2009年下降至51.0%。822株肺炎链球菌最常见的型/群是19群,其次是23、6、14、3、其他。PNSP在6种血清型/群中所占的比例在2004~2009年期间无显著性变化(P〉0.05)。肺炎链球菌对其他β内酰胺类抗生素的非敏感趋势类似青霉素,对红霉素、四环素的非敏感率始终在60%以上,其中青霉素耐药肺炎链球菌(PRSP)对红霉素和四环素几乎100%耐药,对左氧氟沙星、万古霉素的非敏感率均〈3%。结论:临床分离肺炎链球菌以19群、23群、6群、14群、3群常见;对β内酰胺类抗生素的非敏感率自2007年呈下降趋势,且对左氧氟沙星、万古霉素始终具有较高的敏感性。

关 键 词:肺炎链球菌  血清型/群  耐药性  抗生素

Surveillance on serotype/serogroup distribution and the antimicrobial resistance of Streptococcus pneumoniae isolated from clinical patients between 004-2009
ZHANG Xuehua. Surveillance on serotype/serogroup distribution and the antimicrobial resistance of Streptococcus pneumoniae isolated from clinical patients between 004-2009[J]. http://www.botanicus.org/, 2011, 18(8): 9-11
Authors:ZHANG Xuehua
Affiliation:ZHANG Xuehua Department of Pharmacy,Central Hospital of Yiyang City in Hunan Province,Hunan Province,Yiyang 413000,China
Abstract:Objective:To investigate serotype/serogroup distribution and the trend of antimicrobial resistance of Streptococcus pneumoniae isolated from patients hospitalized for pneumonia in our hospital,so as to provide guidance for rational clical treatment.Methods:822 strains of S.pneumoniae were collected from 2004 to 2009.Minimal inhibition concentrations(MIC) of penicillin,cefuroxime,cefdinir,cefaclor,erythromycin,tetracycline,levofloxacin,vancomycin were determined by E-test.And the isolates were serotyped with the quellung reaction.Results:The prevalence of PCG-nonsusceptible S.pneumoniae(PNSP) isolates increased gradually from 49.4% in 2004,reaching a statistical peak in 2006(67.8%),then decreasing to 51.0% in 2009.Among 822 strains of S.pneumoniae,the most prevalent serogroups/serotypes were type 19,23,6,14,3,others.The distribution of 6 serotypes in PNSP isolates was not statistically different between years(P0.05).The prevalence of S.pneumoniae isolates nonsusceptible to other β-lactam antibiotics,similar to penicillin.The prevalence of strains nonsusceptible to erythromycin and tetracycline were consistently60%.Almostly all PCG-resistant S.pneumoniae(PRSP) were resistant to both erythromycin and tetracycline throughout the period.The prevalence of strains resistant to levofloxacin and vancomycin were 3% over the period.Conclusion:Serotype/serogroup 19,23,6,14,3 are the commom types among the S.pneumoniae.Decreased prevalence of β-lactam resistant strains has been occurring since 2007.And These S.pneumoniae strains are highly sensitive to levofloxacin and vancomycin consistantly.
Keywords:Streptococcus pneumoniae  Serotype/serogroup  Antimicrobial resistance  Antibiotics
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