长期应用他汀类药物对心肌梗死患者血脂、心室重构及左室功能的影响

目的观察长期应用他汀类药物治疗心肌梗死的疗效。方法70例心肌梗死患者分为他汀类药物调血脂治疗组（n=37）,未服他汀类药物对照组（n=33）,随访2年。分别于治疗前和治疗后测定总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、左心室舒张期末内径（LVEDD）、左心室收缩期末内径（LVESD）、左心室舒张期末容积（LVEDV）、左心室收缩期末容积（LVESV）和左心室射血分数（LVEF）。结果长期使用他汀类药物可明显降低心肌梗死患者的TC及LDL-C水平（P〈0.01）,改善LVESD和LVEF（P〈0.05）。结论长期使用他汀类药物能降低心肌梗死患者的血脂水平,且对心肌梗死患者心室重构及射血功能均有疗效。

Effects of Long Term Statins Treatment on Blood Lipid and Left Ventricular Function in Patients with Myocardial Infarction

Objective To observe the curative effects of long term statins treatment on blood lipid and left ventriclar function of myocardial infarction patients. Methods 70 patients with myocardial infarction were randomly divided into two groups: Statins treatment group (n=37) and control group (n=33). The level of blood lipid, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF) were mearsured before and 2 years after the treatment. Results The long term applies of statins can bring statistically different (P<0.05) of TC and LDL-C to myocardial infarction patients. LVESD and LVEF were statistically different (P<0.05) before and after statins were used. Conclusion The long term applies of statins can improve the lipidic metabolism and left ventricular function after myocardial infarction.