| 基质金属蛋白酶与慢性阻塞性肺疾病形成机制的关系 |
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| 引用本文： | 马晋,汪伟民.基质金属蛋白酶与慢性阻塞性肺疾病形成机制的关系[J].国际呼吸杂志,2007,27(7):531-535. |
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| 作者姓名： | 马晋 汪伟民 |
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| 作者单位： | 230022,合肥,安徽医科大学第一附属医院老年呼吸内科 |
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| 摘 要： | 基质金属蛋白酶是一类在结构和功能上具有相似性的锌（Zn^2＋）钙（Ca^2＋）离子依赖性蛋白酶超家族。能降解肺组织细胞外基质（ECM）中的多种蛋白成分，导致ECM合成与降解失衡，并与细胞因子相互作用，在慢性阻塞性肺疾病的易感性，炎性反应和气道重构的过程中发挥重要作用。
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| 关 键 词： | 基质金属蛋白酶 慢性阻塞性肺疾病 炎症反应 气道重构 基因多态性 |
Relationship between matrix metalloproteinases and pathogenesis of chronic obstructive pulmonary disease |
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| MA Jin,WANG Wei-min.Relationship between matrix metalloproteinases and pathogenesis of chronic obstructive pulmonary disease[J].International Journal of Respiration,2007,27(7):531-535. |
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| Authors: | MA Jin WANG Wei-min |
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| Abstract: | Matrix metalloproteinases (MMPs) comprise a large family of metalloendopeptidases with Zn2+ and Ca2+ with the similar structure and function.Some of them can degrade many kinds of protein components of the extracellular matrix,and interact with cytokines.Then,MMPs play an important role in the process of airway remodeling and inflammation,as well as the susceptibility of chronic obstructive pulmonary disease(COPD). |
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| Keywords: | Matrix metalloproteinases Chronic obstructive pulmonary disease Airway remodeling Inflammation Genetic polymorphism |
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