| FTY720预防大鼠肾脏缺血再灌注损伤的实验研究 |
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| 引用本文： | 王长希,赵亮,陈立中,陈规划. FTY720预防大鼠肾脏缺血再灌注损伤的实验研究[J]. 中国中西医结合肾病杂志, 2005, 6(1): 17-19 |
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| 作者姓名： | 王长希 赵亮 陈立中 陈规划 |
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| 作者单位： | 1. 中山大学附属第一医院器官移植外科,广州,510080
2. 中山大学附属第三医院肝移植中心,广州,510630 |
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| 基金项目： | 教育部留学回国人员科研启动基金，广东省自然科学基金 |
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| 摘 要： | 目的:研究新型免疫抑制剂FTY720对大鼠肾脏缺血再灌注损伤(IRI)的预防作用.方法:制备大鼠肾脏IRI模型,从下腔静脉注入不同剂量的FTY720,观察术后第1、2、3、5、7 d血清肌酐值(Scr)和术后第2、7 d外周血淋巴细胞数(PLC)的变化,并在术后第2 d取肾脏作组织学检查观察急性肾小管坏死的情况.结果:FTY720处理组动物术后Scr水平显著低于对照组并呈剂量依赖性;FTY720处理组术后第2 d的PLC显著低于对照组;组织学检查显示FTY720处理组肾脏的缺血性损伤轻于对照组.结论:FTY720可以减少PLC,对大鼠肾脏IRI有预防作用.
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| 关 键 词： | 肾脏缺血再灌注损伤 大鼠 |
| 修稿时间： | 2004-09-18 |
Study of FTY720 on Prevention of Ischemia-reperfusion Injury in Rat Kidneys |
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| WANG Changxi,ZHAO Liang,CHEN Lizhong,et al. Study of FTY720 on Prevention of Ischemia-reperfusion Injury in Rat Kidneys[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2005, 6(1): 17-19 |
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| Authors: | WANG Changxi ZHAO Liang CHEN Lizhong et al |
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| Abstract: | Objective:To study the effect of FTY720 on prevention of ischemia-reperfusion injury in rat kidneys.Methods:Ischemia-reperfusion injury model in rat kidney was established and FTY720 at different dose was injected into the inferior vena cava. Changes in serum creatinine was monitored 1, 2, 3, 5 and 7 day after operation and peripheral blood lymphocyte count was measured on day 2 and 7.Kidneys were fixed for histological analysis of the severity of acute tubular necrosis. Results:The groups treated with FTY720 showed lower postoperative creatinine level dose-dependently compared with the control group. FTY720-treated groups also showed less PLC than the control group. The histological analysis showed that the FTY720-treated groups had less histological change of ischemic injury than that of control group.Conclusion:FTY720 can decrease PLC and prevent ischemia-reperfusion injury in rat kidneys. |
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| Keywords: | FTY720 |
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