| 人肺来源的间充质干细胞对T淋巴细胞增殖的影响 |
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| 引用本文： | 向明章,蒋耀光,王慧春,林一丹.人肺来源的间充质干细胞对T淋巴细胞增殖的影响[J].第三军医大学学报,2006,28(10):1052-1053. |
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| 作者姓名： | 向明章 蒋耀光 王慧春 林一丹 |
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| 作者单位： | 1. 第三军医大学,新桥医院胸外科,重庆,400037
2. 第三军医大学,大坪医院野战外科研究所全军胸外科中心,重庆,400042 |
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| 摘 要： | 目的探讨来源于人肺的间充质干细胞(MSCs)是否具有免疫调控能力。方法采用流式细胞术鉴定其免疫表型,用淋巴母细胞转化实验观察其是否具有免疫调控能力。结果①MSCs不表达引起免疫反应的细胞表面分子HLA- DR、CD86、CD80等;②随MSCs细胞量增多,抑制T细胞增殖能力越强。结论人肺来源的间充质干细胞具有免疫调控能力。
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| 关 键 词： | 肺 间充质干细胞 免疫调控 |
| 文章编号： | 1000-5404（2006）10-1052-02 |
| 收稿时间： | 2006-01-23 |
| 修稿时间： | 2006-03-23 |
Human lung-derived mesenchymal stem cells inhibit T lymphocyte proliferation |
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| XIANG Ming-zhang,JIANG Yao-guang,WANG Hui-chun,LIN Yi-dan.Human lung-derived mesenchymal stem cells inhibit T lymphocyte proliferation[J].Acta Academiae Medicinae Militaris Tertiae,2006,28(10):1052-1053. |
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| Authors: | XIANG Ming-zhang JIANG Yao-guang WANG Hui-chun LIN Yi-dan |
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| Institution: | 1. Department of Thoracic Surgery, Xinqiao Hospital, Chongqing 400037; 2.Thoracic and Cardiovascular Surgery Research Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China |
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| Abstract: | Objective To investigate the immunoregulatory ability of human lung-derived mesenchymal stem cells (MSCs) on T cells. Methods MSCs were isolated and cultured from human fetal lung. The immune phenotype was tested by flow cytometry and T lymphocyte proliferation assessed by thymidine incorporation. Results HLA-DR, CD86, and CD80 were not expressed in human lung-derived mesenchymal stem cells. The proliferation of peripherial blood-derived T cells was suppressed and this suppression seemed dependent on the concentration of MSCs. Conclusion Human lung-derived MSCs have been proved to possess immunomodulatory ability. |
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| Keywords: | lung mesenchymal stem cell immunomodulation |
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