中医实热证的研究及改进设想

对中医实热证的造模方法及评价指标进行文献整理及分析。根据CNKI、万方、维普等数据库检索国内外31篇相关文献和课题体会,从实热证的造模方法、评价指标等方面对中医实热证的研究进行论述。结果可知中医实热证的造模方法主要根据"物极必反"原则,选用补气药造模;根据化学因素、客观指标、药物反证为依据复制动物模型造模;根据化学因素、客观指标、药物反证为依据,复制动物模型造模;模拟发生热性病的病因,以细菌、病毒、内毒素等作为致毒材料,通过给动物体内注入大肠埃希菌、巴氏杆菌、肺炎双球菌产生内毒素或直接注入内毒素造模4种,评价指标可以从细胞因子、激素分泌、体液免疫等方面进行概括。中医实热证的造模方法及评价指标近年来取得很大的进展,但借鉴西医造模方法为多。为此提出改进设想,从转化医学的角度建立与中医临床密切的中医实热证模型,参考并移用中兽医的诊断技术,尽可能建立中医动物模型望、闻、问、切四诊评价指标与体系。

Research and Improvement Ideas of Traditional Chinese Medicine Real Heat Syndrome

According modeling methods and evaluation index of traditional Chinese medicine(TCM) real heat syndrome to literature review and analysis.According to the related literature at home and abroad of and subject experience, to discusse TCM real heat syndrome from the modeling methods, evaluation indexes. Tthere are have four modeling methods of TCM real heat syndrome and discusse evaluation index from cytokines,hormone secretion,humoral immune and so on.Although modeling methods and evaluation index of TCM e real heat syndrome has made a lot of progress in recent years, which is referenced Western medicine modeling methods. From the point of science translational medicine establishment TCM real heat syndromes model close to Chinese medicine clinical, to put forward the improvement ideas, reference and diagnostic Chinese veterinarian technology, to established animal model of TCM at four diagnostic methods and evaluation index system as far as possible.