2型糖尿病合并冠心病与同型半胱氨酸及胱抑素C的相关性分析

目的探讨2型糖尿病(T2DM)合并冠心病(CHD)与同型半胱氨酸(HCY)及胱抑素C(CysC)的关系及二者相关性。方法选择确诊T2DM患者151例分为T2DM组(89例)和T2DM合并CHD(T2DM+CHD)组(62例)]及健康者50例(对照组),检测血清HCY、CysC水平,进行比较分析。结果 T2DM组血清HCY、CysC水平高于对照组(P<0.05),T2DM+CHD组高于T2DM组(P<0.05);T2DM合并CHD组血清HCY与CysC呈显著正相关(r=0.649,P<0.05)。结论 T2DM患者体内存在HCY、CysC水平异常,合并CHD患者更为显著,且HCY、CysC水平具有相关性,二者联合检测可有助于了解病情、指导治疗及判断预后。

HCY and CysC correlation analysis in T2DM combined with CHD

Objective To explore the relationship between homocysteine（HCY）,cysteine C（CysC） and type 2 diabetes mellitus（T2DM） combined with coronary heart disease（CHD） and the correlation between them. Methods 151 cases of patients with T2DM, including 89 cases of T2DM（T2DM group） and 62 cases combined with CHD （T2DM＋CHD group） ,and 50 cases of healthy subjects（control group） were detected and compared for serum levels of HCY and CysC. Results Serum levels of HCY and CysC in T2DM group were higher than those in control group （P〈0.05） ,and those in T2DM＋CHD group were higher than in T2DM gorup（P〈0.05）. In T2DM＋CHD group, there was positive correlation between HCY and CysC（r=0. 649 ,P〈0.01）. Conclusion The levels of HCY and Cy- sC might be abnormal in patients with T2DM,especially in patient combined with CHD. There could be correlation between HCY and CysC. Combined detection of these tow indicators could be helpful for the understanding of patho- genetic condition, guiding treatment and prognosis.