南宁地区妇女人乳头状瘤病毒感染的患病率和分布调查研究

目的调查南宁市高危型人乳头状瘤病毒(HPV)感染及亚型分布情况,为预防子宫癌前病变、宫颈癌提供依据。方法通过聚合酶链反应-反向斑点杂交法对6 372例妇女进行HPV DNA基因结果分型。结果 6 372例样本(年龄18～70岁)总体HPV阳性率占全部患者的27.5%,其中阳性患者中78.0%为单一型感染,22.0%为多重感染;HPV16型(20.3%)是多种HPV类型中最常见的基因型,其次为HPV52型(19.9%)、58型(14.0%)、11型(10.6%)、6型(8.9%)。通过年龄分层显示,在18～29岁高危型HPV感染率出现一个高峰。高危型HPV感染率较高的有HPV16、HPV52、HPV58型。结论该调查提供了南宁地区妇女患病率以及常见基因类型的分布,同时也表明HPV基因类型的感染存在地域差异。

The prevalence and distribution investigation of women HPV in Nanning

Objective To investigate high-risk human papilloma virus （HPV） infection and subtype distribu- tion in nanning,and to provide the basis for the prevention of precancerous lesions,cervical cancer. Methods 6 372 cases of women HPV DNA gene typing by polymerase chain reaction and reverse dot blot hybridization. Results 6 372 cases （aged 18-70 years） HPV postive rate of total patients was 27.5% ,among them 78.0% patients for single type infection, 22.0 % for multiple infections Type HPV16 （20.3%） was the most common genotype in various types of HPV, followed by type HPV52 （19.9%）,HPV 58 （14.0%）,HPV 11 （10.6%）,HPV 6 （8.9%）. High-risk HPV infection rate appeared a peak at the age of 18-29 by age stratification. High-risk HPV infection rate from high to low was type HPV16, HPV52, HPV58, HPVll and HPV6. Conclusion The survey provides the distribution of prevalence rate of women in Nanning and common gene types,and also indicates the existence of regional differences in HPV gene type of infection.