| 阿司匹林铜胶囊含量的RP—HPLC测定及其稳定性考察 |
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| 引用本文： | 刘祝东. 阿司匹林铜胶囊含量的RP—HPLC测定及其稳定性考察[J]. 中国医药工业杂志, 2001, 32(3): 130-132 |
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| 作者姓名： | 刘祝东 |
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| 作者单位： | 昆明贵金属研究所, |
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| 基金项目： | 国家“九·五”攻关项目(95-722-26-01)。 |
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| 摘 要： | 采用RP－HPLC法测定阿司匹林铜胶囊及其杂质水杨酸铜含量，辅料不干扰分析。阿司匹林铜和水杨酸铜的平均回收率分别为99．5％（RSD＝0．55％）和99．6％（RSD＝0．8％），且线性关系良好,r分别为0．9953和0．9965。稳定性实验表明：阿司匹林铜胶囊对光稳定，在高温、潮湿环境下极不稳定，应密封于阴凉处储存。
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| 关 键 词： | 阿司匹林铜 水杨酸铜 RP－HPLC 稳定性 测定 抗炎药 |
| 文章编号： | 1001-8255(2001)03-130-03 |
| 修稿时间： | 1999-11-15 |
Determination of Copper Aspirinate Capsules by HPLC |
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| LIU Zhu Dong. Determination of Copper Aspirinate Capsules by HPLC[J]. , 2001, 32(3): 130-132 |
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| Authors: | LIU Zhu Dong |
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| Abstract: | Copper aspirinate capsules and the impurity copper salicylate were determined by RP HPLC. The average recoveries of copper aspirinate and copper salicylate were 99.5% ( RSD =0.55%) and 99.6% ( RSD =0.80%), respectively. They had good linearities with r of 0.9953 and 0.9965, respectively. The stability test results showed that copper aspirinate capsules should be kept in the dry and cool place. |
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| Keywords: | copper aspirinate copper salicylate RP HPLC stability determination |
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