血清IL-23水平与溃疡性结肠炎严重程度的相关性研究

目的：观察血浆IL-23与溃疡性结肠炎（UC）严重程度的相关性，探讨IL-23在UC发病中的作用机制。方法采用酶联免疫吸附试验分别检测64例UC患者及59例健康人群血清IL-23的水平。分别比较缓解期、正常对照组与活动期UC患者的IL-23水平的差异；比较缓解期患者与正常对照组的差异；比较重度溃疡性结肠炎患者与轻、中度患者血清IL-23的水平的差异。结果活动期UC患者血清IL-23的水平相对于缓解期和正常对照组差异有统计学意义（P〈0.01）；缓解期UC患者血清IL-23的水平相对于正常对照组差异无统计学意义（P〉0.05）；重度UC患者血清IL-23的水平显著高于轻、中度组（P〈0.01）。结论 IL-23在UC病情的发生发展中可能起着重要作用；血清IL-23可作为标志物反映UC的病情程度。

Research on correlation of serum IL-23 concentrations with the severity of ulcerative colitis

Objective To observe correlation of serum IL-23 concentrations with the severity of ulcerative colitis and to explore the role of IL-23 on the pathogenesis of UC mechanism. Methods Serum IL-23 levels were examined with ELISA methods in 64 patients with US whereas 59 healthy people being control group. The active and releasing phases of UC were differed and the difference were also compared between slight moderate and sever groups. Results The concentration of serum IL-23 in active UC was significant higher than in releasing UC and control group （P〈0.01）. The level had no significant difference between releasing UC and contrast group （P〉0.05）. The level in severe group was higher than that in moderate and slight group （P〈0.01）. Conclusion IL-23 plays a crucial role in the development of UC. The examination of IL-23 levels in plasma may be crucial to reflect the severity of UC.