PAGET'S EXTENSION OF ESOPHAGEAL CARCINOMA: Immunohistochemical and Mucin Histochemical Evidence of Paget's Cells in the Esophageal Mucosa |
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Authors: | Yoko Norihisa Kennichi Kakudo Yutaka Tsutsumi Hiroyasu Makuuchi Takashi Sugihara Toshio Mitomi |
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Affiliation: | Department of Pathology, Tokai University School of Medicine, Isehara;Department of Surgery, Tokai University School of Medicine, Isehara |
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Abstract: | A 68-year-old male with Paget's disease of the esophagus is reported. The underlying primary esophageal carcinoma was diagnosed as adenosquamous cell carcinoma on the basis of the presence of both adenocarcinoma and epidermoid carcinoma components. There was invasive growth of clear Paget's cells in the esophageal epithelium. Mucin histochemistry disclosed common characteristics of mucin between Paget's cells and adenosquamous cell carcinoma. It was histochemically confirmed that the existence of mucin was a general feature of extramammary Paget's disease. In 13 control esophageal carcinomas including three with adenocarcinomatous elements, Paget's cells were not found in the epithelium. To date only one case of Paget's disease of the esophagus has been described in the literature. |
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Keywords: | Key words: Paget's disease Adenosquamous cell carcinoma Esophagus Metastasis Esophageal carcinoma |
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