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IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
Affiliation:1. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA;2. Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA;3. Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA;4. Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA;5. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA;6. University of Pittsburgh School of Medicine, Medical Scientist Training Program, Pittsburgh, PA 15213, USA;7. Department of Pharmaceutical Science, Marshall University School of Pharmacy, Huntington, WV 25701, USA;8. Washington University School of Medicine, Department of Pediatrics, Division of Newborn Medicine, St. Louis Children’s Hospital, St. Louis, MO 63110, USA;9. Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan;10. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;11. Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA;12. Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA 70112, USA;13. Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA
Abstract:
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  • Keywords:Th17  IL-17A  Lgr5  ATOH1  stem cell  progenitor cells  secretory cell lineage  intestine  organoids
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