Antibody therapeutics targeting ion channels: are we there yet? |
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| Authors: | Han Sun Min Li |
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| Institution: | 1.Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA |
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| Abstract: | The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases. |
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| Keywords: | ion channel antibody autoimmune neurological disorder channelopathy protein-based therapeutics |
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