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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
Affiliation:1. Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9 Canada;2. Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8 Canada;3. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA;4. Blood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA;5. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA;6. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Abstract:
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  • Keywords:interferon regulatory factor 2  IRF2  type I interferon  interferon gamma  T cell exhaustion  cancer  immunotherapy  adoptive cell transfer  CyTOF
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